Categories
Cure Research

Predicting remission

Article from Australia – remission is defined as being able to discontinue treatment for at least 8 weeks and still not have any reaction to peanut.

This was a group of 162 children treated between the ages of 1 and 10 with peanut flour +/-probiotics, not Palforzia.

The higher your peanut blood IgE level is at baseline, the lower your chance of achieving remission. But there is no clear cut off:

Young children tend to have lower IgEs, which might be why they are more likely to achieve remission according to IMPACT study and others – in this study, the age they started treatment did not predict remission, once you correct for IgE.

Categories
Research Under 4s

Safety of peanut OIT in young children in a clinic setting

Study from Canada – 69 children under the age of 3 reached maintenance dose of peanut over a median of 29 weeks (so slightly more than 6 months, on average).

One patient had a peanut ingestion-related emergency department (ED) visit requiring adrenaline during initial dose escalation (first day).

During the first year of maintenance phase, no patients had peanut ingestion-related ED visits nor required adrenaline.